Author's response to reviews Title: Effect of Tadalafil on blood flow, pain, and function in chronic cold Complex Regional Pain Syndrome: A randomized controlled trial Authors:

Effect of tadalafil on blood flow, pain, and function in chronic cold Complex Regional Pain Syndrome: a randomized controlled trial

BACKGROUND This double-blind, randomized, controlled trial investigated the effect of the phosphodiesterase-5 inhibitor tadalafil on the microcirculation in patients with cold Complex Regional Pain Syndrome (CRPS) in one lower extremity. METHODS Twenty-four patients received 20 mg tadalafil or placebo daily for 12 weeks. The patients also participated in a physical therapy program. The primar...

Author's response to reviews Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate Title: cold type complex regional pain syndrome type 1 Authors: J. George Groeneweg (j.groeneweg@erasmusmc.nl)

Author's response to reviews Title: The effect of a sports chiropractic manual therapy intervention on the prevention of back pain, hamstring and lower limb injuries in semi-elite Australian Rules footballers: a randomized controlled trial Authors:

No recovery of cold complex regional pain syndrome after transdermal isosorbide dinitrate: a small controlled trial.

The microcirculation appears to be impaired in cold chronic complex regional pain syndrome (CRPS). This double-blind, placebo-controlled, randomized trial investigated the effect of the nitric oxide (NO) donor isosorbide dinitrate (ISDN) on the peripheral blood flow in patients with chronic CRPS. Twenty-four patients received 1% ISDN in Vaseline or a placebo ointment applied to the dorsum of th...

Immediate Effect of Respiratory Muscle Sprint-Interval Training (RMSIT) on the Plantar Pressure Variables in Athletes with Chronic Low Back Pain: A Randomized Controlled Trial

Objectives: The respiratory function is often overlooked in people with Low Back Pain (LBP), while it is one of the factors for the continuation and recurrence of lumbar spine injury. Aim of this study was survay the immediate effect of Respiratory Muscle Sprint-Interval Training (RMSIT) on the plantar pressure variables of athletes with LBP. Methods: This randomized controlled trial was condu...